Bioluminescent Stem-Loop Probes (BLSP)

Our research focuses on the development of novel bioluminescent SLPs (BSLPs) that provide unprecedented sensitivity and selectivity for RNA sensing and demonstrate its application in sensing of viral persistency. The development of a BSLP would enhance sensitivity of current SLP-based detection systems by retaining the rugged versatility and broad applicability of its fluorescent counterparts while exhibiting low background and high detection sensitivity and the negligible effect of matrix on biouminescne signal will provide for rapid detection of RNA using BSLPs in any sample matrix.


Paper Fluidic-based Viral and Bacterial Detection Technologies for Resource-Poor Settings

Our laboratory focuses on a variety of nucleic acid detection strategies including reporter probe hybridization, rolling circle amplification, and incorporation of zinc-finger binding protein tags in order to develop technologies suitable for the detection of viruses and bacteria for resource-poor settings. These nucleic acid detection methods are adapted to paper-based detection for the development of portable, inexpensive platforms.

Multifunctional Platforms for Targeted Gene Delivery and Enhanced Intracellular Trafficking

Reports in the early 1990s established the feasibility of transferring naked plasmid DNA into skeletal muscle.